由camrelizumab诱导的眼的反应性皮肤毛细血管内皮扩散:一个病例报告
Xuecong Zhou1, Xiaoming Yan1, Yuan Wu1
1Department of Ophthalmology, Peking University First Hospital, Peking University, Beijing 100034, P.R. China.
Biomedical reports
|February 15, 2024
概括
这项案例研究突出了眼部反应性皮肤毛细血管内皮扩散 (RCCEPs) 的罕见实例,该病例发生在接受编程细胞死亡蛋白1抑制剂camrelizumab治疗的患者身上. 及时识别和管理这些与免疫相关的不良事件对于患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 免疫检查点抑制剂 (ICI),如camrelizumab,越来越多地用于癌症治疗.
- 这些疗法可以导致由于免疫系统调节而导致与免疫相关的不良事件 (irAEs).
- 反应性皮肤毛细血管内皮扩散 (RCCEPs) 是与camrelizumab相关的已知不良事件.
研究的目的:
- 报告一种罕见的眼部RCCEPs病例,该病例是由camrelizumab (SHR-1210) 诱导的.
- 强调识别irAEs异常分布的重要性.
- 讨论癌症患者免疫相关毒性的管理.
主要方法:
- 一名用camrelizumab治疗的宫癌患者的病例报告.
- 对不良事件的临床观察和记录.
- 关于RCCEP和ICI相关毒性的文献综述.
主要成果:
- 患者在治疗宫癌的卡梅利祖马布治疗后出现了眼部RCCEPs.
- 眼部呈现的RCCEPs是不常见的,典型分布在头部,子,干部和四肢.
- 患者的病情需要针对异常的病变分布进行特殊的管理.
结论:
- 眼部RCCEPs是卡姆雷利祖马布治疗的罕见但可能的不良事件.
- 及时诊断和适当的治疗,可能包括对症状性病变进行外科切除,至关重要.
- 对非典型的irAE表现的认识对于有效的癌症治疗管理至关重要.
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