肥胖和与年龄相关的白内障之间的关联:对前性队列研究的更新系统审查和剂量反应元分析
Sana Niazi1,2, Majid Moshirfar3, Mohammad H Dastjerdi4
1Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran, Iran.
Frontiers in nutrition
|February 15, 2024
概括
较高的体重指数 (BMI) 与与年龄相关的白内障 (ARC) 和后部亚囊白内障 (PSC) 的风险增加有关. 每增加5公斤/平方米的BMI,ARC风险会增加6%,PSC风险会增加27%.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 关于肥胖和与年龄有关的白内障 (ARC) 之间的关联存在不一致的发现.
- 按体重指数 (BMI) 定义的肥胖是一个日益严重的公共卫生问题.
- 了解ARC的风险因素对于预防策略至关重要.
研究的目的:
- 系统地审查和元分析前性队列研究关于BMI和ARC之间的关联.
- 进行剂量反应元分析以量化BMI和ARC风险之间的关系.
- 调查肥胖和不同类型的与年龄有关的白内障之间的联系.
主要方法:
- 在PubMed,Scopus,ISI知识网和谷歌学者中进行系统的文献搜索,直到2022年6月.
- 包括16项前性队列研究,其中有1,607,125名参与者.
- 分析比较最高和最低的BMI类别和剂量反应分析.
主要成果:
- 较高的BMI与ARC风险增加有关 (RR: 1.18) 和后部亚囊性白内障 (PSC) (RR: 1.44).
- 每增加5kg/m2的BMI与ARC风险增加6% (RR: 1.06) 和PSC风险增加27% (RR: 1.27) 相相关.
- 在较高的BMI和皮质白内障风险之间发现了积极的关联 (RR:1.20);对于核白内障没有观察到显著的关联.
结论:
- 根据BMI指出的肥胖与ARC,PSC和皮质白内障的风险增加有关.
- 这些发现表明BMI和某些白内障类型的风险之间存在剂量反应关系.
- 在BMI和核白内障之间没有发现显著的关联.
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