在长期航天飞行之前和期间,宇航员的肺氧化
Lars L Karlsson1, Lars E Gustafsson1, Dag Linnarsson1
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Frontiers in physiology
|February 15, 2024
概括
宇航员 宇航员 宇航员
科学领域:
- 太空医学 太空医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 宇航员在太空任务期间面临有毒尘埃暴露的风险.
- 呼出氧化的部分压力 (PENO) 是气道炎症的非侵入性生物标志物.
- 肺部NO循环受重力和气体密度的影响,这些因素在空间中发生了变化.
研究的目的:
- 研究微重力和降低大气压对宇航员呼出的氧化部分压力 (PENO) 的影响.
- 评估PENO作为在太空飞行期间肺部健康变化的监测器.
- 评估不同大气压对PENO测量的影响.
主要方法:
- 十名宇航员在飞行前 (1G) 和飞行后 (微重力) 进行了监测.
- 测量包括50毫升/秒的PENO (PENO50),气膜NO和气道NO流量.
- 六名宇航员也在降低大气压 (0.7ATA) 下进行了研究.
主要成果:
- 在观察期间,PENO50随着时间的推移而下降 (p=0.0284).
- 与1G (2.28mPa) 相比,PENO50在微重力 (1.65mPa) 中明显较低,减少了27%.
- 大气压的降低并没有影响PENO50,但增加了气道NO的贡献.
结论:
- 观察到的PENO50变化表明最初的呼吸道炎症随着时间的推移而消失.
- 宇航员的基线PENO50应在相关的重力条件下确定.
- 在太空任务期间,PENO监测可能需要根据重力和大气压力进行调整.
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