最近在zwitterionic纳米尺度药物递送系统的进展,以克服生物障碍
Xumei Ouyang1, Yu Liu1, Ke Zheng2
1Zhuhai Institute of Translational Medicine, Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, China.
Asian journal of pharmaceutical sciences
|February 15, 2024
概括
兹维特里昂纳米级药物递送系统 (nDDS) 通过克服生物障碍和避免加速血液清理 (ABC) 来提高治疗效率,与传统的PEGylated nDDS不同. 这些先进的系统承诺更简单的设计,以提高临床翻译.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 纳米级药物递送系统 (nDDS) 提高治疗效率,但面临生物障碍的挑战.
- 聚乙烯糖醇 (PEG) 修饰 (PEGylation) 是标准的,但在重复服用时会导致加速的血液清理 (ABC).
- 紫聚合物由于其抗污染特性,为PEG提供了一个有前途的替代品.
研究的目的:
- 审查zwitterionic nDDS在克服生物障碍方面的进展.
- 分析zwitterionic nDDS绕过生物障碍的机制.
- 在临床应用中讨论zwitterionic nDDS的未来前景和挑战.
主要方法:
- 文献综述的最新进展在zwitterionic纳米尺度的药物输送系统.
- 分析zwitterionic nDDS与生物系统相互作用的机制.
- 与PEGylated对应物相比,Zwitterionic nDDS性能的评估.与PEGylated对应物相比.
主要成果:
- 与PEGylated系统相比,Zwitterionic nDDS表现出优越的生物相容性和抗污染特性.
- 这些系统有效地克服了生物障碍,包括细胞膜和 lysosomal 降解.
- 双胞胎性nDDS表现出延长的血液循环时间,并避免ABC现象.
结论:
- 在药物输送的PEGylated系统上,Zwitterionic nDDS代表了显著的进步.
- 它们绕过多种生物障碍的能力简化了nDDS的设计,并促进了临床翻译.
- 对理性设计的进一步研究对于优化用于疾病治疗的zwitterionic nDDS至关重要.
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