喉状细胞癌的IL-17表达和预后
1Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Ear, nose, & throat journal
|February 15, 2024
概括
在相邻的正常组织中高IL-17表达可能预测喉状细胞癌 (LSCC) 的预后不佳. 邻近正常组织中CD8表达率低也表明预后不佳,可能反映LSCC患者抗瘤免疫力下降.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 促炎性细胞因子IL-17在各种癌症中起作用.
- 在喉状细胞癌 (LSCC) 中IL-17的预后意义仍然不清楚.
研究的目的:
- 调查LSCC中IL-17和相关标记物的预后价值.
- 评估IL-17表达和患者生存结果之间的关联.
主要方法:
- 免疫组织化学染色用于评估67名LSCC患者的IL-17,IL-23,CD8,CD31和血管内皮生长因子表达.
- 卡普兰-梅尔分析和考克斯比例风险模型被用于确定生存率和确定预后变量.
主要成果:
- 在LSCC组织中,IL-17和IL-23的表达显著高于相邻的正常 (AN) 组织.
- 在AN组织中高IL-17表达,宫淋巴结转移 (CLNM),高级TNM阶段,差异化和高微血管密度 (MVD) 与较差的整体存活率 (OS) 有关.
- 考克斯回归确定了CLNM,瘤组织中的高MVD和AN组织中的低CD8表达作为较差OS的显著预测因素.
结论:
- 在AN组织中高IL-17表达可能作为LSCC的潜在预后标志物.
- 在AN组织中CD8的低表达可能表明前线抗瘤免疫力受损,并且与LSCC的预后不佳有关.
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