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Updated: Jul 3, 2025

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影响内动脉瘤风险的药物类别:遗传相关性和门德尔随机化

Ynte M Ruigrok¹, Jan H Veldink¹, Mark K Bakker¹

¹Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.

European stroke journal

|February 15, 2024

概括

这项研究没有发现任何药物可以预防内动脉瘤 (IA) 破裂或动脉瘤下arachnoid出血 (ASAH). 抗抑郁药可能会增加IA和ASAH风险,特别是在高响应者中,突出显示了与药物相关的复杂致病机制.

科学领域:

遗传学和药理学遗传学和药理学
神经科学和神经病学神经科学和神经病学
药物发现和开发药物发现和开发

背景情况:

内动脉瘤 (IA) 和脑下动脉瘤出血 (ASAH) 缺乏非侵入性预防性治疗方法.
确定影响IA责任的药物类别对于制定预防策略至关重要.
遗传方法提供了一种探索药物-AI关系的新方法.

研究的目的:

用遗传方法确定可能影响内动脉瘤 (IA) 责任的药物类别.
评估与IA遗传相关的药物类的因果关系和治疗潜力.
了解IA和ASAH背后的致病机制.

主要方法:

利用全基因组关联总结统计数据计算IA/ASAH和23种药物类别中药物使用之间的遗传相关性.
采用三种门德尔随机化框架来评估相关药物类的因果关系和治疗潜力.
分析了药物责任,独立于高血压作为危险因素.

主要成果:

对抗抑郁药,甲,乙盐酸,阿片类药物,β-阻断剂和治疗胃潰瘍/胃食道逆流症的药物观察到遗传相关性.
在基因预测的药物使用和IA之间没有发现因果关系;然而,抗抑郁药物的高响应者在使用这些药物时显示IA和ASAH风险增加.
慢性疼痛的遗传责任,止痛药的使用 (偏醇,阿司匹林,阿片类药物) 和IA之间存在复杂的,潜在的类关系.

结论:

没有确定的药物降低了IA和ASAH的责任.
抗抑郁药的使用,特别是在遗传倾向的个体中,可能会增加IA和ASAH的责任.
这项研究揭示了IA,疼痛和各种药物类别之间的类关系,增强了对IA病变的理解.

关键词:

内动脉瘤是一个内动脉瘤.门德尔的随机化药物类药物类药物类药物类药物反应药物反应遗传学遗传学遗传学是一个脑下关节下部出血

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