在COVID-19中发生的二次感染:死前和死后培养研究研究
Vandana V Kiro1, Meenakshi Sharma2, Sharad Srivastava3
1Department of Microbiology, Division of Forensic Pathology and Molecular DNA, New Delhi, India.
Indian journal of pathology & microbiology
|February 15, 2024
概括
研究了住院COVID-19患者的二次细菌感染. 在活体和已死亡患者中发现了抗药性病原体,如Acinetobacter baumannii和Klebsiella pneumoniae,这表明它们在死亡率中发挥了作用.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 关键护理医学 关键护理医学
背景情况:
- 二次性细菌感染使COVID-19在6-15%的患者中复杂化住院治疗.
- 了解这些感染对于患者的治疗结果至关重要.
研究的目的:
- 在住院COVID-19患者中调查二次细菌感染.
- 为了确定已故COVID-19患者样本的细菌学概况.
主要方法:
- 在北印度的一家三级护理中心进行的前性研究 (2020年7月至2021年4月).
- 对268名患者的样本 (死前和死后) 的分析,包括鼻口腔抽样,血液,组织,尿液和脑脊液.
主要成果:
- 鉴定出常见的病原体:宝曼尼菌 (死前43.1%,死后44.1%),肺炎菌 (死前36.3%,死后25.5%) 和大肠杆菌 (死前11.3%,死后20.9%).
- 所有孤立的病原体都表现出高抗微生物耐药性.
- 在死前和死后样本中,细菌概况相似.
结论:
- 在死前和死后样本中类似的细菌概况表明,抗性病原体和COVID-19死亡率之间存在联系.
- 强调在严重的COVID-19病例中,抗菌素耐药性感染的严重负担.
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