在沙特阿拉伯的炎症性肠道疾病患者中,爱斯坦-巴尔病毒的血清流行率
Badr Al-Bawardy1,2,3, Abdulaziz F Alfadley1, Mohammed Almousallam1
1College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
概括
在沙特阿拉伯,16.8%的炎症性肠病 (IBD) 患者没有接触到爱斯坦-巴尔病毒 (EBV). 年龄较小预测EBV不暴露,突出了IBD患者在提奥普林治疗前需要EBV检测.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 在炎症性肠病 (IBD) 患者中,爱斯坦-巴尔病毒 (EBV) 的血清流行率在全球范围内有所不同.
- 在沙特阿拉伯的IBD患者中,没有关于EBV血清发病率的先前数据.
- 这项研究通过检查沙特第三级护理中心的EBV血清流行来解决这个差距.
研究的目的:
- 在被诊断患有炎症性肠病 (IBD) 的患者中确定爱斯坦-巴尔病毒 (EBV) 的血清流行率.
- 在IBD队列中确定与EBV血清阳性相关的因素.
- 评估EBV血清转化率在最初对EBV负的患者中.
主要方法:
- 记录了EBV状态的IBD患者 (年龄≥14) 的回顾性图表审查.
- 从2018年1月1日到2023年1月1日收集的数据.
- 分析包括EBV血清流行的主要结果和相关因素和血清转化率的二次结果.
主要成果:
- 分析了150名IBD患者;16.8% (n=25) 没有先前暴露于EBV.
- 年龄较小与EBV不暴露显著相关 (平均年龄26岁与31.2岁).
- 在40岁以上的患者中,EBV血清流行率最高 (92.9%),在14-25岁的患者中最低 (78.2%). 血清转化发生在16.7%的EBV-naïve患者中.
结论:
- 在这个沙特队列中的IBD患者中,很大一部分 (16.8%) 是EBV-naïve,年轻年龄是关键预测因素.
- 这些发现支持在IBD患者开始提奥普林治疗之前进行常规EBV状态评估.
- 在这个人群中,EBV血清发病率并不普遍,这强调了治疗前查的重要性.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
184
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
184
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334