多种因素影响了细胞癌患者手术治疗的决策
Britt-Inger Kröger Dahlin1, Jan Hlodan1, Ramin Ghaffarpour1
1Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Scandinavian journal of urology
|February 15, 2024
概括
细胞癌 (RCC) 的手术策略取决于瘤大小,T期,世卫组织绩效状况和并发症指数. 功能不是RCC患者选择治疗的独立因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
背景情况:
- 细胞癌 (RCC) 的手术策略受患者功能的影响.
- 部分切除术 (PN) 比彻底切除术 (RN) 更好地保持功能,降低慢性病 (CKD) 风险.
- 本研究评估了功能和其他临床变量在RCC手术治疗选择中的重要性.
研究的目的:
- 确定功能和临床变量对细胞癌 (RCC) 手术治疗选择的影响.
- 确定影响部分切除术 (PN) 和彻底切除术 (RN) 之间的选择的关键因素.
主要方法:
- 在1994年至2018年期间治疗663名RCC患者的回顾性分析.
- 收集的数据包括估计的膜过率 (eGFR),世卫组织绩效状况 (WHO-PS),查尔森并发症指数 (CCI),瘤阶段,大小和患者人口统计.
- 统计分析采用了曼-惠特尼U,奇平方测试和后勤回归.
主要成果:
- 在663名患者中,455人接受了RN,208人接受了PN.
- 术前的eGFR在PN组 (80.8) 与RN组 (77.1) 相比,在PN组 (80.8) 中更高.
- 后勤回归显示瘤大小,T期,WHO-PS和CCI显著影响了治疗选择;eGFR,M期,年龄和性别没有.
结论:
- 瘤大小,CCI,T阶段和WHO-PS显著影响RCC的手术策略.
- 在T1a RCC患者中,瘤大小和WHO-PS是治疗选择的独立预测因素.
- 调整后的分析表明,功能与RCC患者的治疗策略没有独立的关联.
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