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甲状腺激素在左心室非紧缩的长期预后值

L Liu¹, S Cai², A Chen¹

¹Cardiac Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.

Journal of endocrinological investigation

|February 15, 2024

概括

在患有左心室非紧缩 (LVNC) 的患者中,低水平的自由三甲氨酸 (FT3) 预测了更糟糕的心血管结果. 这一发现强调了FT3作为LVNC患者的关键预后标志物.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
内部医学内部医学

背景情况:

甲状腺功能显著影响心血管疾病的预后.
左心室非紧缩 (LVNC) 是一种罕见的先天性心脏缺陷,与不良心血管事件相关.

研究的目的:

调查甲状腺激素对LVNC患者心血管不良结果的预测价值.
确定自由三甲状腺素 (FT3) 作为LVNC的潜在预后生物标志物.

主要方法:

一项对388名LVNC患者进行的纵向队列研究,其中包括完全的甲状腺功能和心血管评估.
用多变量考克斯回归和受限立方线分析来评估预测因素.
患者通过FT3三位体进行分层,并进行亚组分析.

主要成果:

在5.22年的时间里,25.3%的患者出现了初级结局 (心脏死亡/心脏移植),33.5%的患者出现了重大心血管不良事件 (MACE).
低FT3独立地与增加的初级和二级心血管不良结果有关.
较低的FT3水平与严重的心脏功能障碍,重塑和较高的死亡率/MACE相关,特别是在特定的子组中.

结论:

低血清FT3是LVNC患者心血管不良结果的独立预测因子.
将FT3纳入风险评分可以改善LVNC中MACE的预测.
甲状腺激素水平,特别是FT3,对于管理和预测LVNC的预后至关重要.

关键词:

自由的三甲氨基氨酸.左心室非紧缩的情况主要的不良心血管事件.死亡率死亡率死亡率甲状腺功能甲状腺功能

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