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使用便携式光谱仪开发现场治疗药物监测方法

Kenichiro Todoroki¹, Nan Fukudo², Yuto Kudoh²

¹Department of Analytical and Bioanalytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

|February 15, 2024

概括

一种新的在场方法用于科米辛 (VCM) 治疗药物监测 (TDM) 提供快速的血量化在10分钟内. 这种基于便携式光谱仪的方法确保在床边可靠的VCM水平评估,以优化患者治疗.

科学领域:

临床化学临床化学
分析化学分析化学
药理动力学药理动力学

背景情况:

治疗药物监测 (TDM) 对于优化万科米辛 (VCM) 疗效和安全至关重要.
目前的VCM TDM方法通常需要集中实验室分析,导致结果延迟.
护理点TDM为更快的临床决策提供了潜力.

研究的目的:

开发和验证一种快速的现场方法来监测万科米治疗药物.
使用便携式光谱仪与现有的免疫突变测试试剂用于VCM量化.
为了使床边VCM水平评估能够及时进行治疗调整.

主要方法:

在现场使用便携式光谱仪开发TDM方法.
适应商业上可用的免疫度测定试剂用于VCM量化.
方法与理论值,HPLC-UV和自动化临床化学分析仪的验证.

主要成果:

在10分钟内在血样本中快速定量VCM.
与理论VCM值的良好相关性 (R = 0.995).
与HPLC-UV (R ² = 0.970) 和自动分析仪 (R ² = 0.951) 相比,可靠性高.
日内精度<12.5%和日间精度<17.7%.

结论:

在现场开发的TDM方法提供了准确可靠的科米量化.
这种便携式快速测定可促进床边治疗药物监测.
预计该方法将改善适当的万科米辛药物治疗的评估.

关键词:

检查点的护理测试.一个便携式的光谱光度计.治疗药物监测治疗药物监测范科米辛是一种药物.

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相关概念视频

UV–Vis Spectrometers

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.