在重组疹疫苗接种后,疹疹眼科复发的风险
Anushka Walia1, Yuwei Sun2, Nisha R Acharya2,3,4
1School of Medicine, University of California, San Francisco.
JAMA ophthalmology
|February 15, 2024
概括
重组疹疫苗 (RZV) 可能会增加疹眼科 (HZO) 复发的风险,在患者有先前的HZO病史. 建议在接种疫苗后对HZO复发进行监测.
科学领域:
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
- 疫苗学 疫苗学 疫苗学
背景情况:
- 重组疫苗 (RZV) 建议用于19岁及以上的成年人.
- RZV有效地预防疹眼科炎 (HZO).
- 在有HZO病史的患者中存在关于RZV的安全问题.
研究的目的:
- 评估先前有HZO诊断的患者在RZV给药后HZO复发的风险.
主要方法:
- 一项回顾性队列研究分析了来自16,408名患有HZO事件的患者的索赔数据.
- 接受RZV后HZO诊断的患者与未接种疫苗的患者进行了比较.
- 精确的k:1匹配用于控制混因素.
主要成果:
- 接种疫苗后56天内HZO复发的发生率在RZV组为每1000人年37.7,而未接种疫苗组为每1000人年26.2.
- 经RZV暴露后HZO复发的调整危险比为1.64 (95% CI,1.01-2.67;P=.04).
- 暴露于RZV与HZO复发的可能性更高有关.
结论:
- 在有HZO病史的患者中,RZV的使用与HZO复发的风险增加有关.
- 对于这一组患者,建议对HZO复发进行疫苗接种后监测.
- 可能需要进一步的研究来探索降低风险的策略.
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