代谢学识别和验证血清安德罗二作为新型生物标志物用于诊断主角闭合光眼,并预测视野进展
Shengjie Li1,2,3,4,5, Jun Ren1, Zhendong Jiang1
1Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
eLife
|February 15, 2024
概括
这项研究确定了androstenedione作为一种关键的代谢物生物标志物,用于诊断初级角闭眼光病 (PACG) 和预测其进展. 较高的androstenedione水平表明PACG患者的视野下降速度更快.
科学领域:
- 眼科医生 眼科 眼科
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
背景情况:
- 主要闭角光眼 (PACG) 是亚洲不可逆转失明的主要原因.
- 目前的临床实践缺乏可靠的PACG诊断和预测生物标志物.
- 代谢变化越来越多地被识别在玻璃眼患者.
研究的目的:
- 开发和验证用于诊断PACG的代谢物生物标志物.
- 为了识别预测PACG视野进展的生物标志物.
- 探索代谢变化在PACG病原发生中的作用.
主要方法:
- 这是一项多中心,五阶段的研究,涉及616名参与者.
- 广泛针对的代谢学和化学发光免疫试验被采用.
- 五个机器学习算法被用来识别最佳候选生物标记物.
主要成果:
- 血清androstenedione在发现和验证阶段 (AUC从0.85到1.0) 显示了PACG诊断的优异差异化.
- 安德罗二有效地区分了PACG严重程度 (AUC 0.92-0.98) 并与水性幽默水平相关联.
- 较高的基线androstenedione水平与更快的视野进展显著相关 (HR=2.71,p=0.017).
结论:
- 血清androstenedione是诊断PACG的一个有前途的生物标志物.
- 安德罗二水平可以表明PACG患者视野进展的风险.
- 这一发现为改善PACG管理和早期干预提供了潜力.
关键词:
安德罗斯二一个.诊断 诊断 诊断 诊断 诊断 诊断人类 人类 人类 人类 人类 人类 人类医学 医学 医学 医学 医学代谢生物组的代谢生物组预测 预测 预测 预测主角闭合 玻璃眼 玻璃眼视野的进展 视野的进展更多相关视频
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