前额外投射调节岛内皮层的反复回路,以支持短期记忆
Jian Yao1, Ruiqing Hou2, Hongmei Fan2
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Lingang Laboratory, Shanghai 200031, China.
Cell reports
|February 15, 2024
概括
从中部前额皮层 (mPFC) 到前部角质岛皮层 (aAIC) 的长距离大脑连接对短期记忆 (STM) 至关重要. 调节这些mPFC-aAIC通路直接影响记忆性能和神经通信.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 短期记忆 (STM) 依赖于神经电路,但远程和局部连接之间的相互作用尚未完全理解.
- 中间前额叶皮层 (mPFC) 和前层角质岛皮层 (aAIC) 参与记忆任务,但它们在STM中的具体相互作用尚不清楚.
研究的目的:
- 调查从mPFC到aAIC的远程投影在支持短期内存编码中的作用.
- 为了确定这些投影如何影响神经活动,功能连接和在嗅觉延迟反应任务期间在aAIC内的信息传输.
主要方法:
- 在头部固定小鼠中利用光遗传学和电生理学,执行嗅觉延迟反应任务.
- 分析了尖峰-曲线图数据,以评估记忆神经元之间的功能合 (FC).
- 通过光遗传学 (抑制和激发) 操纵mPFC-aAIC投影,观察对行为和神经活动的影响.
主要成果:
- 对mPFC-aAIC投影的光遗传抑制损害了行为表现,减少了记忆神经元的比例,并在aAIC内减少了记忆特异性FC.
- 这些投影的光遗传激发增强了行为表现,增加了记忆神经元,并加强了特定于记忆的FC.
- mPFC-aAIC投影双向调节了STM信息传输到下游神经元的有效性.
结论:
- 从mPFC到aAIC的远程投影在支持短期内存编码方面发挥着至关重要的作用.
- 这些前额外射线积极调节岛屿神经元的功能连接和记忆编码能力.
- 这些发现阐明了一种关键的机制,即前额外岛屿相互作用有助于短期记忆.
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