揭示了卵细胞中介成熟过程中PKA抑制和Cdk1激活之间的相互作用

Martina Santoni1, Ferdinand Meneau1, Nabil Sekhsoukh1

  • 1Sorbonne Université-CNRS, Laboratoire de Biologie du Développement Institut de Biologie Paris Seine, LBD-IBPS, 75005 Paris, France.

Cell reports
|February 15, 2024
PubMed
概括

激素刺激通过降低蛋白激酶A (PKA) 的调节触发卵细胞成熟,从而导致Cdk1的激活. 这项研究揭示了PKA抑制如何调节循环B1和Mos积累,驱动G2/M过渡.

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