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相关概念视频

Nuclear Transmutation03:20

Nuclear Transmutation

17.5K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
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Subatomic Particles03:37

Subatomic Particles

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Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
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Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

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In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
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Types of Radioactivity03:23

Types of Radioactivity

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The most common types of radioactivity are α decay, β decay, γ decay, neutron emission, and electron capture.
Alpha (α) decay is the emission of an α particle from the nucleus. For example, polonium-210 undergoes α decay:
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Proton (¹H) NMR: Chemical Shift01:07

Proton (¹H) NMR: Chemical Shift

1.7K
Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei...
1.7K
Nuclear Stability03:18

Nuclear Stability

18.8K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
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相关实验视频

Updated: Jul 3, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

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质子是新的第一响应者

Bingxu Liu1

  • 1Institute for Protein Design, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|February 15, 2024
PubMed
概括

我们对免疫系统及其复杂的防御机制的了解有了重大进步.

科学领域:

  • 免疫学
  • 分子生物学
  • 细胞生物学

背景情况:

  • 干扰素基因刺激剂 (STING) 是先天免疫的一个关键蛋白.
  • 它在感知循环二核酸和启动免疫反应方面的作用已得到充分证实.
  • 然而,除了信号外,它的精确分子功能仍然难以捉摸.

研究的目的:

  • 研究人类的新型结构和功能性质.
  • 确定STING是否具有超出其在免疫信号传递中的职能.
  • 为了阐明SING新发现的功能背后的分子机制.

主要方法:

  • 使用X射线结晶学来确定人类STING的高分辨率结构.
  • 进行生物化学测试以评估STING的离子通道活性.
  • 使用基于细胞的测试来评估STING通道功能在免疫反应中的生理相关性.

主要成果:

  • 在细胞膜中形成一个功能性的离子通道.
  • 这种通道活动由STING的激活状态及其与循环二核酸的相互作用来调节.
  • 对于免疫信号分子的有效转移,STING通道功能被证明是关键的.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

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结论:

  • 发现STING的离子通道功能代表了理解先天免疫力的转变.
  • 这一发现为针对STING介导免疫路径的治疗干预开辟了新的途径.
  • 作为一个信号中心和通道的双重作用突出了它对主机防御的复杂和多方面的贡献.