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可调节的氧化释放的不同材料厚度的制

Patrick Maffe¹, Ryan Devine¹, Mark Garren¹

¹School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia, USA.

Journal of biomedical materials research. Part B, Applied biomaterials

|February 15, 2024

概括

聚合物薄膜的厚度会影响氧化物 (NO) 从中释放出来. 调整厚度允许可调节的NO输送,这对于优化医疗器械性能至关重要.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
医疗设备工程医疗设备工程

背景情况:

膠 (SR) 是一種廣泛使用的醫療級聚合物.
对于释放氧化 (NO) 的SR进行修改已被探索.
像薄膜厚度这样的材料特性对NO释放动学的影响仍然没有得到充分的研究.

研究的目的:

研究皮膜厚度对氧化 (NO) 供体储存,吸收和释放的影响.
分析聚合物厚度和NO释放动力学之间的关系.
为了确定厚度作为优化医疗级聚合物中NO释放的关键参数.

主要方法:

制造不同厚度的皮膜.
装载NO的捐赠者进入的矩阵.
随着时间的推移,测量和分析NO释放特征.
的释放动态与薄膜厚度的相关性.

主要成果:

证明了膠薄膜厚度和NO釋放特性之間的直接關係.
观察到可调节的NO释放动力学受聚合物厚度的影响.
确定薄膜厚度显著影响NO捐赠者的储存和释放.

结论:

聚合物薄膜厚度是控制膠釋放NO的關鍵因素.
厚度提供了一个可调节的参数,用于优化医疗设备的NO输送.
这项研究为设计先进的NO释放医疗材料提供了基础的见解.

关键词:

这是一种S-nitrosothiol-N-acetylpenicillamine.氧化氧化的使用方法聚二甲基西洛二氧化.聚合物厚度的聚合物制的是一种.溶剂的胀溶剂的胀

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Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...