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Sang M Nguyen¹, Huong T T Tran^2,3, Jirong Long¹

¹Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

JCO global oncology

|February 15, 2024

概括

乳腺癌手术和诊断延迟显著减少肠道微生物群的多样性. 高纤维摄入量也会影响微生物组成,导致癌症患者的肠道微生物组不健康.

科学领域:

微生物组研究的研究.
在瘤学瘤学.
人类健康人类健康人类健康

背景情况:

肠道微生物组是人类健康的组成部分,受到癌症及其治疗的影响.
了解乳腺癌和肠道微生物群之间的相互作用对于患者的治疗结果至关重要.

研究的目的:

为了研究越南乳腺癌患者的肠道微生物组合.
确定肠道微生物特征与临床/社会人口学因素之间的关联.

主要方法:

来自356名越南乳腺癌患者的便样本的枪式基因组测序.
分析肠道微生物多样性,种群丰富性和肠道微生物群健康指数 (GMHI).
评估与社会人口统计学,临床因素和瘤特征的关联.

主要成果:

与手术前样本相比,手术后样本的α和β多样性明显较低.
在患者中观察到不健康的肠道微生物组 (低GMHI) 的高患病率.
诊断延迟与减少的α-多样性和改变的β-多样性有关;高纤维摄入与较低的α-多样性和特定细菌属丰富相关.

结论:

乳腺癌手术,诊断延迟和高纤维摄入量有助于肠道微生物群变得不那么多样化和不健康.
在越南,手术后的抗生素预防会加剧微生物组的改变.
这些发现强调了临床干预和生活方式对乳腺癌患者肠道微生物群的影响.

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