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左心室部分特定的运动评估,用于心脏门放射手术
Justin Poon1,2, Richard B Thompson3, Marc W Deyell4
1Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
心脏放射手术使用心脏磁共振成像来跟踪心脏运动. 心脏门显著减少了心室动脉冲动的治疗区域,提高了精度.
科学领域:
- 心血管成像和干预心血管成像和干预
- 辐射瘤学 辐射瘤学
- 心脏电生理学 心脏电生理学
背景情况:
- 心脏放射外科手术提供一种非侵入性的方法来治疗心室动脉冲动.
- 精确准心律失常的区域对于治疗疗效至关重要.
- 了解心脏运动对于优化辐射输送至关重要.
研究的目的:
- 用心磁共振 (CMR) 电影图像来量化左心室 (LV) 分段特定运动.
- 通过分析心脏循环期间的运动来评估心脏门放射手术的潜在益处.
- 为了评估对照组和心力衰竭患者的细分特定运动变化,减少喷射率 (HFrEF).
主要方法:
- 在50名对照组和50名HFrEF患者中分析了CMR屏住呼吸的电影图像和LV轮点.
- 将轮点划分为17个解剖细分,以定义假设的治疗目标.
- 确定最佳治疗窗口,测量心脏中心位移和治疗区域,有或没有心脏门.
主要成果:
- 全运动心脏位移在6-14毫米 (控制) 和4-11毫米 (HFrEF) 之间.
- 心脏门在两组中都将心脏中心部位位移减少到1毫米.
- 心脏门在对照组中显著减少了38%-53%的治疗区域,在HFrEF患者中减少了26%-48%.
结论:
- 心脏循环运动是心脏放射外科手术整体目标运动的重要因素.
- 分段特定的心脏运动在心脏的不同解剖区域有所不同.
- 心脏关门有可能大幅减少治疗量,提高心脏放射外科手术的精度.
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