优化道轨迹的穿越时间,用于质子弧疗法治疗计划
V Wase1, O Marthin1, A Fredriksson1
1RaySearch Laboratories AB, Stockholm, Sweden.
Physics in medicine and biology
|February 15, 2024
概括
算法弧轨道优化方法 (ATOM) 快速计算出用于质子弧疗法 (PAT) 的最佳门架速度配置文件. 这种工具有助于最大限度地减少治疗时间,以便在不改变现有计划或硬件的情况下更快地分娩.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 计算生物学 计算生物学
背景情况:
- 质子弧疗法 (PAT) 是一种先进的辐射技术,在治疗期间涉及连续的门架或患者旋转.
- 一个关键的感知PAT的好处是减少治疗的持续时间,虽然实际的交付时间在很大程度上仍未确定.
- 目前的局限性包括没有商业上可用的PAT交付机器.
研究的目的:
- 介绍算法弧轨道优化方法 (ATOM),以确定高效的门架速度配置文件,以快速交付PAT计划.
- 在不修改治疗计划或硬件的情况下,使PAT交付时间最小化.
- 为临床整合提供估计PAT交付时间的工具.
主要方法:
- 通过优化门架速度,ATOM计算出最短的交付轨迹.
- 确保在定义的物理约束 (速度,加速度,冲动) 范围内提供足够的时间进行点位传输和能量层切换.
- 采用离散的门架速度,A*算法和鲁基格运动生成库以实现动态可行性.
主要成果:
- ATOM用256个离散速度在不到一秒的时间内计算了360个能量层的弧形轨迹.
- 在180个能量层中,证明的传递时间为284s (肝脏),288s (前列腺) 和309s (头部和部).
- 在合成数据和临床病例上验证了算法的效率.
结论:
- ATOM是一个开源的C++库,具有Python接口,用于快速生成速度配置文件.
- 它作为确定质子弧交付时间的有效工具.
- 可以将ATOM集成到治疗规划工作流程中,以优化PAT交付.
相关概念视频
Additional Routes of Drug Administration
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Routes of Drug Administration: Overview
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Curing Methods
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
Dosage Interval and Administration Route: Determination Methods
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to individual...
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Design Example: Alignment of a Road Line Using GIS
The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...


