相关实验视频

Updated: Jul 3, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

IL-37-Smad3对ox-LDL诱导的内皮细胞功能障碍的多重保护作用

Changyi Zhang¹, Xiaojun Huang¹, Bin Xie¹

¹Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou City, Guangdong province, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|February 15, 2024

概括

干白素-37 (IL-37) 通过减少内细胞网膜应激 (ERS) 和由氧化低密度脂蛋白 (ox-LDL) 引起的自,减轻动脉样硬化. 这种保护作用是通过与Smad3的结合来实现的,这提供了一个潜在的治疗策略.

科学领域:

心血管生物学心血管生物学
免疫学免疫学免疫学
细胞应激反应的应激反应

背景情况:

动脉样硬化是一种由氧化低密度脂蛋白 (ox-LDL) 驱动的炎症性动脉疾病.
氧化LDL通过内细胞网膜应激 (ERS) 诱导内皮功能障碍.
众所周知,互白素-37 (IL-37) 具有血管保护功能.

研究的目的:

调查IL-37是否可以减轻ox-LDL诱导的ERS和自.
探索IL-37作为动脉样硬化的治疗剂的潜力.

主要方法:

使用的老鼠冠状动脉内皮细胞 (RCAECs) 用ox-LDL和IL-37治疗.
评估了伤口愈合率,骨质生成因子的表达和ERS通路蛋白.
采用Smad3静音和电子显微镜来检查IL-37/Smad3复合物的作用.

主要成果:

在RCAEC中,IL-37减轻了牛LDL诱导的伤口愈合率的增加.
IL-37降低了ox-LDL诱导的亲骨质性反应,ERS和自.
这些效应依赖于Smad3,因为沉默Smad3取消了保护性反应.
电子显微镜证实IL-37/Smad3复合物抑制了内细胞网膜自.

结论:

通过抑制ERS和自,IL-37可以缓解由ox-LDL诱导的内皮功能障碍.
这种保护机制涉及IL-37/Smad3复合体.
IL-37显示出作为动脉样硬化多重保护性治疗剂的潜力.

关键词:

细胞内膜网膜应激 (ERS) 是一种压力.介质蛋白-37-37 介质蛋白-37 介质蛋白-37 氧-LDL是一种LDL.这真是太疯狂了

更多相关视频

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

Published on: June 21, 2013

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

相关概念视频

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...