在甲基胺使用障碍中改变自发的神经活动及其与认知功能的关联
Yanan Zhou1, Winson Fu Zun Yang2, Qiuxia Wu3
1Department of Psychiatry, Hunan Brain Hospital (The Second People's Hospital of Hunan Province), Changsha, China; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Asian journal of psychiatry
|February 15, 2024
概括
甲基胺使用障碍改变了大脑活动,特别是在左侧膜,这与认知缺陷有关. 这些发现突出了理解和治疗甲基胺使用障碍患者认知障碍的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 成研究 研究成研究
背景情况:
- 甲基胺 (MA) 是一种被广泛滥用的物质,已知具有有害影响.
- 对于MA对认知功能和潜在的神经机制的具体影响仍然不太了解.
- 这项研究侧重于患有甲基胺使用障碍 (MUD) 的个人.
研究的目的:
- 研究MUD患者的认知功能和大脑功能成像之间的关系.
- 为了确定与MUD相关的大脑活动的特定变化.
- 为了将这些大脑活动变化与认知表现相关联.
主要方法:
- 该研究包括45名被诊断患有MUD的患者和43名健康对照 (HC).
- 用MATRICS共识认知电池评估认知功能.
- 使用3.0特斯拉磁共振成像获得功能性大脑数据.
主要成果:
- 与HC相比,MUD患者在各种大脑区域显示出区域同质性 (ReHo) 和低频波动幅度 (ALFF) 的变化.
- 具体来说,较低的ReHo在双边后中心,左上和左语言区域观察到.
- 在MUD组中,在双边状和左侧膜中发现了更高的ALFF,在双边后中心皮层和左中间带状皮层中发现了更低的ALFF.
- 在右侧中后皮层的ReHo与迷宫测试的表现正相关.
- 左门中的ALFF与数字符号编码,连续性能和迷宫测试分数负相关.
结论:
- 患有MUD的个体在自发大脑神经活动中表现出显著的改变.
- 左门中自发神经活动的强度与MUD患者的认知功能密切相关.
- 这些发现表明,大脑活动的改变,特别是在门中,在与甲基胺使用相关的认知缺陷中起着至关重要的作用.
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