在转移性细胞癌中因其他原因死亡率的差异根据部分和激进切除术和年龄:倾向性得分与研究结果相匹配
Carolin Siech1, Reha-Baris Incesu2, Simone Morra3
1Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Goethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, Germany.
Surgical oncology
|February 15, 2024
概括
部分切除术减少了转移性细胞癌的年轻患者因其他原因的死亡率. 然而,在70岁及以上的老年患者中没有观察到这种生存益处.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 手术瘤学手术瘤学
背景情况:
- 转移性细胞癌 (mRCC) 在患者管理中构成了重大挑战.
- 在mRCC患者中,部分切除术 (PN) 的生存益处尚未得到充分证实,特别是在老年人群中.
研究的目的:
- 在不同年龄组的转移性细胞癌患者中,研究部分切除术与其他原因死亡率之间的关联.
- 确定PN的生存优势是否延伸到患有mRCC的老年患者.
主要方法:
- 利用监测流行病学和最终结果 (SEER) 数据库来获取患者数据.
- 包括被诊断患有转移性细胞癌的患者,他们接受了部分或彻底的切除术.
- 雇员倾向得分匹配,卡普兰-梅尔生存分析和多变量考克斯回归来分析结果.
主要成果:
- 分析了2390名患有mRCC的患者,按年龄分层:<60,60-69和≥70岁.
- 部分切除术与60岁以下 (HR 0.22) 和60-69岁 (HR 0.38) 患者的其他原因死亡率显著降低有关.
- 在70岁以上的患者中,对部分切除术没有观察到其他原因死亡率的显著降低.
结论:
- 部分切除术在患有转移性细胞癌的年轻和中年患者中显示出生存益处.
- 这些发现表明,对于70岁及以上的mRCC患者来说,部分切除可能没有益处.
- 建议对患有转移性细胞癌的年轻患者考虑进行部分切除术,以潜在地改善生存结果.
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