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Updated: Jul 3, 2025

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

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用多光谱分析,分子对接和分子动态模拟来研究wedelolactone与人血清白蛋白的结合

Yali Liu1, Zhen Yuan1, Pan Zhao1

  • 1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Biophysical chemistry
|February 15, 2024
PubMed
概括

韦德洛 (WED) 与人血清白蛋白 (HSA) 通过自发结合相互作用,主要是通过键和范德瓦尔斯力. 这种相互作用发生在I位点,形成一个稳定的复合体,并改变HSA的结构,影响WEL的药物开发.

关键词:
人类血清专素的人类血清专素分子对接是分子对接.分子动态模拟的分子动态模拟.多种光谱分析分析.我们用了Wedelolactone.

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