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扩散基谱成像和扩散张力成像预测了多发性硬化症中持续的黑洞形成

Lindsey Wooliscroft¹, Amber Salter², Gautam Adusumilli³

¹Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Department of Neurology, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Multiple sclerosis and related disorders

|February 15, 2024

概括

扩散基谱成像 (DBSI) 和扩散张力成像 (DTI) 可以预测多发性硬化症 (MS) 的持久黑洞 (PBHs). 在急性病变中,较高的DBSI非受限制分数和较低的DBSI受限制分数表明未来的组织破坏.

科学领域:

神经成像是一种神经成像.
放射学放射学是一门学科.
多发性硬化症研究研究

背景情况:

扩散基谱成像 (DBSI) 通过分析多个扩散张力提供比扩散张力成像 (DTI) 更高的本病特异性.
多发性硬化症 (MS) 中的持续性黑洞 (PBH) 表示严重的组织损伤,与增加的残疾相关.
从急性对比增强病变 (CEL) 预测PBH发展对于了解MS进展至关重要.

研究的目的:

评估DBSI和DTI指标对急性CEL在12个月内演变为PBH的预测能力.
调查急性CEL和随后的PBH形成中的特定扩散参数 (DBSI和DTI) 之间的关系.

主要方法:

一项前性队列研究,涉及复发性多发性硬化症患者,至少有一个CEL.
每月进行4-6个月的MRI扫描,以跟踪CEL直到gadolinium分辨率.
在最大CEL显现时量化DBSI和DTI指标,至少12个月后进行随访MRI以确定PBHs.

主要成果:

在20个成员国的164个CEL中,59个 (36%) 演变成了PBH.
在成为PBH的CEL中,DTI辐射扩散率 (RD) 和轴向扩散率 (AD) 显著增加.
0.45以上的DBSI非受限制分数 (表明胀/细胞外空间) 和0.07以下的DBSI受限制分数是PBH发展的显著预测因素.

结论:

根据DBSI指标,急性CEL内的胀和细胞外空间增加预示着随后的组织破坏和PBH形成.
DBSI指标,特别是非受限制和受限制分数,在预测PBH在MS的发展方面表现有前途.

关键词:

扩散基础光谱成像成像技术扩散张力成像的成像方法增强病变的病变增强病变的病变多发性硬化症是一种多发性硬化症.持久的黑洞是持久的黑洞.

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