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Updated: Jul 3, 2025

Quantification of Ethanol Levels in Zebrafish Embryos Using Head Space Gas Chromatography
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胚胎氧化DNA损伤,胚胎病变和神经发育障碍的BRCA1蛋白剂量依赖风险,无论是否暴露于乙醇

Danielle M Drake1, Kian Afsharian1, Benjamin Or2

  • 1Department of Pharmaceutical Sciences and Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

Redox biology
|February 15, 2024
PubMed
概括

降低的BRCA1蛋白水平增加了对来自氧化应激的发育障碍的易感性. 即使是轻微的BRCA1缺陷也会导致胎儿DNA损伤和胚胎病变,特别是当暴露于酒精 (乙醇) 时.

关键词:
酒精 (乙醇,EtOH) 的使用情况乳腺癌1感受性基因 (Brca1)条件淘汰 (cKO) 鼠标模型模型在DNA损伤和修复过程中.发育障碍 发育障碍 发展障碍胎儿酒精谱系障碍 (FASD) 是一个疾病.淘汰赛 (KO) 鼠标模型模型反应性氧物种 (ROS) 是一种反应性氧物种.

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