治疗耐药抑郁症的psilocybin辅助心理治疗:一个随机临床试验评估重复剂量的psilocybin的随机临床试验
Joshua D Rosenblat1, Shakila Meshkat2, Zoe Doyle2
1Braxia Health, Canadian Rapid Treatment Centre of Excellence (CRTCE), Braxia Scientific, Mississauga, ON, Canada; University of Toronto, Toronto, ON, Canada.
Med (New York, N.Y.)
|February 15, 2024
概括
松素辅助心理治疗 (PAP) 在治疗耐药抑郁症的复杂患者中显示出可行性和抗抑郁作用. 重复剂量增强了抑郁症严重程度的降低,表明安全性和耐受性.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 松素辅助心理治疗 (PAP) 显示出抗抑郁作用的前景.
- 以前的试验往往排除了复杂的患者群体.
- 这项研究研究了PAP在治疗耐药性抑郁症与自杀性和并发性疾病中的可行性.
研究的目的:
- 在复杂的患者群体中确定PAP的可行性.
- 评估PAP的安全性和耐受性.
- 为了评估在六个月内灵活,重复服用西的抗抑郁药的疗效.
主要方法:
- 患有耐治疗重度抑郁症或双相II型精神障碍的成年人被随机分配到即时或等待名单PAP.
- 参与者接受了1-3次25毫克psilocybin与准备和整合治疗.
- 使用蒙哥马利-阿斯伯格抑郁症评分表 (MADRS) 评估了可行性,安全性,耐受性和疗效.
主要成果:
- 这项研究包括30名参与者 (16名即时,14名等候名单),其中29人被保留到第二周的终点.
- 不良事件是暂时的,没有报告严重的不良事件.
- 与等待名单相比,立即PAP治疗显示MADRS得分的降低明显更大 (Hedge的g = 1.07,p < 0.01).
结论:
- PAP是一种可行的治疗方法,用于患有严重抑郁症和双相情感障碍的复杂患者.
- 观察到初步的抗抑郁药疗效与足够的安全性和耐受性.
- 重复服用psilocybin剂量与抑郁症严重程度的降低有关.
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