抗万科胺素的Enterococcus faecium:结束查和隔离在丹麦大学医院的影响
S G K Hansen1, K Klein1, A Nymark1
1Department of Clinical Microbiology and Infection Control, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Microbiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
The Journal of hospital infection
|February 15, 2024
概括
终止抗万科胺素的Enterococcus faecium (VREfm) 查和隔离并没有增加VREfm细菌病或死亡率. 该研究没有发现证据支持重新引入这些感染控制措施.
科学领域:
- 传染性疾病 传染性疾病
- 医院流行病学 医院流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 医院资源受到越来越多的抗万科米辛和万科米辛变异性肠球菌 (VREfm/VVEfm) 的增长率的压力.
- 在管理VREfm/VVEfm时,平衡患者安全,感染控制和医院费用至关重要.
研究的目的:
- 评估Odense大学医院 (OUH) 中断VREfm/VVEfm查和隔离方案的影响.
- 评估患者特征的变化,与VREfm/VVEfm疾病干预后相关的细菌病风险和死亡率.
- 确定OUH和区域合作医院的VREfm/VVEfm细菌病的负担.
主要方法:
- 一项回顾性队列研究分析了OUH和合作医院2015-2022年的临床隔离物.
- 该研究比较了干预期 (2015-2021) 的数据与查/隔离和干预后期 (2022) 的数据.
- 微生物学数据库和医院记录被用于检索隔离物和患者数据.
主要成果:
- 随着查和隔离的终止,在OUH观察到VREfm/VVEfm指数分离物的增加.
- 在其他参数中,除了范基因的变化之外,还注意到了轻微的,无意义的变化.
- 三十天死亡率与VREfm/VVEfm引起的死亡没有相关性,只有四例可能是由VREfm/VVEfm感染引起的.
结论:
- 尽管索引隔离物增加,但短暂的随访期没有提供证据来恢复VREfm/VVEfm查和隔离协议.
- 这些发现表明,基于这些证据,目前的感染控制策略可能需要重新评估.
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