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一个KDELR介导的ER检索系统通过裂变酵母中的未折叠蛋白质反应调节线粒体功能

Mengdan Zhu1, Zheng Fang1, Yifan Wu1

  • 1MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.

The Journal of biological chemistry
|February 15, 2024
PubMed
概括

缺少KDEL受体 (Erd2) 触发了酵母中展开的蛋白质反应 (UPR),增强了线粒体呼吸和反应性氧物种的细胞存活. 这揭示了ER检索在细胞平衡中发挥的新角色.

关键词:
在这里,你会看到一个很棒的景点.戈尔吉戈尔吉是一座古老的城市.KDELRR 在这里.这种植物是Schizosaccharomyces pombe.通过UPR进行全日制检查.线粒体中的线粒体.

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