对评论"基因:评估"的回应
1Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Progress in biophysics and molecular biology
|February 15, 2024
概括
遗传变异不驱动生物进化,挑战了基因作为遗传单位的概念. 这项研究驳斥了epistasis.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 遗传学 是一个
- 热力学是一种热力学.
背景情况:
- 传统观点认为,遗传变异是生物进化的引擎,基因是遗传的单位.
- 长期进化实验 (LTEE) 显示出一种权力法适应性概况,这种模式在自然系统中无处不在地观察到.
- 现有的理论,包括费舍尔的自然选择遗传理论和约翰森的基因型概念,正在被重新评估.
研究的目的:
- 挑战遗传变异在生物进化中的基本作用.
- 断言基因不是遗传的单位.
- 捍卫LTEE的权力法适应性概况,反对像表观论这样的解释,并提出理解进化的一个替代框架.
主要方法:
- 在LTEE和自然系统中观察到的权力法律适应性概况的分析.
- 重新评估历史科学背景,特别是1880年至1911年期间,关于约翰森的基因型概念.
- 将最小作用原理和热力学定律应用于生物系统.
主要成果:
- 史诗并不能解释LTEE的权力法适应性概况;史诗在进化中没有作用.
- LTEE的力量法适应性概况伪造了进化理论的关键原则,包括费舍尔的自然选择遗传理论和约翰森的基因型概念.
- 生物进化是一个通用的热力学过程,而不是热力学原理的例外.
结论:
- 遗传变异不是生物进化的基础,基因不是遗传的单位.
- 最少的作用原则与热力学第二定律同义,支配自然系统,包括有机体为自由能量平衡的努力.
- 对遗传性疾病和特征的全基因组关联研究是误导性的,因为基因的非遗传性质.
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