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情感功能障碍介绍了神经免疫标记物与默认模式网络功能连接之间的联系,以及体征症状在体征症状障碍中的体征症状

Bumhee Park¹, Seulgi Lee², Yuna Jang³

¹Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea; Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon, Republic of Korea.

Brain, behavior, and immunity

|February 15, 2024

概括

情感症状介绍了默认模式网络 (DMN) 连接和体征症状之间的联系,体征症状障碍 (SSD). 神经免疫标记物也影响DMN连接,影响SSD患者的情感症状.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
心理学心理学心理学

背景情况:

阴性症状障碍 (SSD) 的特点是身体症状和功能障碍,通常与抑郁和焦虑同时发生.
在SSD中,情绪症状,默认模式网络 (DMN) 功能连接 (FC) 和外周炎症之间的相互作用仍然不完全理解.

研究的目的:

在SSD患者中探索情感症状,DMN FC和外周炎症之间的关系.
通过调解分析,研究涉及这些因素的潜在调解途径.

主要方法:

招募了119名参与者 (74名SSD患者,45名对照) 进行精神病学评估,血液测试和休息状态fMRI.
评估的神经免疫标记物 (IL-6,hs-CRP,TNF-α,三,血清素,5-HIAA),临床指标 (身体症状,抑郁,焦虑,愤怒,alexithymia),以及DMN FC.
利用相关性和调解分析来检查临床症状,血液指数和DMN FC之间的关系.

主要成果:

与对照人群相比,SSD患者的IL-6和TNF-α水平较高,左下垂体叶区和左前额皮层之间的DMN FC减少.
身体症状严重程度与情感症状正相关,与DMN FC负相关,并与IL-6,TNF-α和酸盐水平相关.
调解分析显示,焦虑和特征愤怒显著调解了DMN FC和体质症状之间的关系. 神经免疫标记物 (hs-CRP,IL-6) 也介导了DMN FC对抑郁症的影响.

结论:

情感症状在调解DMN连接,身体症状和SSD中神经免疫标记之间的关联方面发挥着至关重要的作用.
炎症标志物可能会调解DMN连接对情感症状的影响,突出显示SSD情感失调的重要性.
研究结果表明,将情感症状调解纳入SSD研究中,使用DMN FC或神经免疫标记物,可以改善疾病的预测和解释.

关键词:

焦虑焦虑是一种焦虑.默认模式的网络模式是默认模式.抑郁症抑郁症抑郁症功能连接性的功能连接性.炎症炎症是一种炎症.身体症状障碍身体症状障碍

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