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在PCOS中测量DHEAS水平是否有用?
Hélène Boucher1, Geoffroy Robin1, Louise Ribière1
1Université de Lille, CHU de Lille, 59000 Lille, France.
Annales d'endocrinologie
|February 15, 2024
概括
过高的脱乙二酸盐 (DHEAS) 在少数患有多囊性卵巢综合征 (PCOS) 的女性中被发现. DHEAS水平与其他雄激素相关,但不与卵巢或代谢标志物相关,这限制了其在PCOS的诊断价值.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 雄激素生物学 雄激素生物学
背景情况:
- 多囊性卵巢综合征 (PCOS) 经常与高水平的脱氨硫酸 (DHEAS) 相关,尽管确切的关系尚不清楚.
- 以前的研究可能因与年龄相关的DHEAS下降而产生偏差,需要根据年龄调整的分析.
研究的目的:
- 准确评估使用特定年龄规范在PCOS妇女中增加DHEAS的患病率.
- 研究DHEAS水平与PCOS中的各种临床,荷尔蒙和代谢标志物之间的相关性.
- 为了澄清DHEAS在PCOS病理生理学中的作用.
主要方法:
- 对1223名患有PCOS的妇女和517名对照进行了回顾性横截面研究.
- 使用年龄标准化的标准来评估DHEAS水平.
- 分析了DHEAS和临床/荷尔蒙/代谢参数之间的相关性,根据年龄和BMI进行调整.
主要成果:
- 在PCOS中显著更高的DHEAS升高流行率 (8.1%) 与对照 (4.3%),特别是在表型A和C中.
- DHEAS水平与总,二,17-基孕和年龄正相关.
- 没有发现与AMH,LH,FSH的显著相关性,或与BMI的最小相关性.
结论:
- 年龄调整的DHEAS升高在少数PCOS病例中存在 (8.1%),在特定的表型 (A和C) 中的比例更高.
- DHEAS与其他雄激素相关,但与卵巢,垂体或PCOS中的代谢标志物存在有限的关联.
- DHEAS测试对于诊断PCOS或了解其病理生理学具有有限的实用性,除了非常高的情况.
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