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基于酸的生物材料是否没有遗传毒性? 一个系统的审查

Augusto Monteiro de Souza¹, Marina Rocha do Nascimento Dantas¹, Estefânia Lins Secundo¹

¹Department of Cell Biology and Genetics, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

|February 15, 2024

概括

酸 (HA) 生物材料的基因毒性很小,一些研究甚至表明有保护作用. 然而,纳米结构形式可能会在长期暴露时带来风险,需要进一步的安全评估.

科学领域:

生物材料科学生物材料科学
毒理学毒理学毒理学
遗传学是一个遗传学.

背景情况:

酸 (HA) 是临床和制药应用中普遍存在的生物材料.
现有的研究主要集中在HA的化学特性和生物相容性 (粘附,增殖,分化).
在了解基于HA的生物材料的基因毒性潜力方面存在重大差距.

结论:

虽然通常是安全的,但基于HA的生物材料的基因毒性可以与它们的纳米结构形式 (例如针头,棒) 联系起来.
进一步研究长期暴露于纳米结构HA的影响对于确保人类安全至关重要.
持续监测对于安全的临床和制药使用HA生物材料至关重要.

关键词:

并且具有突变性.基因毒性基因毒性氧亚帕提特是一种氧亚帕提特.纳米颗粒纳米颗粒

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