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用SN38装备的PSMA准的SMART分子.

Emily A Savoy1, Feyisola P Olatunji1, Nooshin Mesbahi1

  • 1Washington State University, Department of Chemistry, Pullman, WA 99164-4630, United States.

Bioorganic & medicinal chemistry letters
|February 15, 2024
PubMed
概括

我们开发了一种针对前列腺特异性膜抗原 (PSMA) 的药物合物,可提供SN38化疗. 结合物显示pH值依赖的有效载荷释放,增强PSMA阳性前列腺癌细胞的疗效.

关键词:
酸性链接剂 酸性链接剂在PSMA上,PSMA可以在PSMA上进行交易.在SMDCDC中使用.SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SSN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN38SN这是一个智能分子.刺激对刺激的反应性.

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