免疫生物学和对食物过敏的治疗
Suzanne Barshow1, Jyothi Tirumalasetty2, Vanitha Sampath3,1
1Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, California, USA.
Annual review of immunology
|February 15, 2024
概括
通过IgE介导的食物过敏是由于免疫耐受性丧失造成的,通常与表皮屏障受损有关. 新的治疗方法正在出现,超出了传统的避免策略.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 胃肠病学 胃肠病学
背景情况:
- 通过IgE介导的食物过敏 (IgE-FA) 涉及免疫耐受性的崩,其特征是2型辅助T细胞 (TH2) 反应.
- 缺陷的上皮屏障 (皮肤,肠道) 越来越多地与IgE-FA的发展有关,促进过敏原暴露和随后的炎症.
- 传统的治疗依赖于避免过敏原和治疗急性反应,但新的治疗方法正在推进.
研究的目的:
- 审查目前对IgE介导的食物过敏病原和免疫生物学的理解.
- 讨论与IgE-FA相关的诊断和预后因素.
- 探索IgE-FA治疗的不断变化的领域,包括免疫疗法和生物药物.
主要方法:
- 关于IgE-FA的发病,免疫生物学,诊断,预后和治疗的文献综述.
- 对表皮屏障和TH2反应的作用的证据综合.
- 对食物过敏治疗的最新进展进行分析.
主要成果:
- 免疫耐受性的丧失和TH2细胞激活是IgE-FA的核心.
- 表皮屏障功能障碍促进过敏原敏感化和过敏性炎症.
- 在开发过敏原特异性免疫疗法和生物制剂方面取得了重大进展.
结论:
- IgE-FA的发病是多因素的,涉及遗传,环境和免疫因素.
- 治疗策略正在转向疾病修饰,而不是仅仅是症状管理.
- 对免疫耐受机制和屏障功能的进一步研究对于开发更有效的治疗方法至关重要.
相关概念视频
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Hypersensitivities
642
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
642
Antibody Structure
60.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.1K
Cross-reactivity
31.1K
Overview
31.1K
Autoimmune Disorders
436
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
436
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334


