健康的生活方式,全身炎症和乳腺癌风险:调解分析
Yanyu Zhang1, Mengjie Song1, Zixuan Yang1
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Xue Yuan Road 1, University Town, 350122, Fuzhou, China.
BMC cancer
|February 15, 2024
概括
健康的生活方式降低了乳腺癌的风险,像C反应蛋白 (CRP) 这样的炎症标志物对这种关联进行了微弱的调解. 系统性炎症可能在乳腺癌发展途径中发挥作用.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 健康的生活方式与降低乳腺癌风险有关.
- 系统性炎症作为这种关联中介的作用尚未完全理解.
研究的目的:
- 调查炎症标志物在健康生活方式指数 (HLI) 与乳腺癌风险之间的关联中的调解作用.
- 量化特定炎症标志物介导的关联百分比.
主要方法:
- 英国生物银行对259,435名女性进行的队列研究分析了9种炎症标志物.
- 考克斯回归模型估计了乳腺癌的危险比率 (HR).
- 调解分析量化了HLI和由炎症标志物调解的乳腺癌之间的关联.
主要成果:
- 较高的C-反应蛋白 (CRP),全身免疫炎症指数 (SII),CRP与白蛋白比率 (CAR),CRP与淋巴细胞比率 (CLR),单细胞与HDL-c比率 (MHR) 和中性粒细胞与HDL-c比率 (NHR) 的水平与乳腺癌风险增加有关.
- HLI和乳腺癌之间的关联由CRP (8.5%),SII (1.71%),CAR (8.66%),CLR (6.91%),MHR (6.27%) 和NHR (7.33%) 弱度介导.
- 在饮食与乳腺癌的关联中,CRP和CAR分别占16.58%和17.20%. 在BMI和腰围与乳腺癌的关联中,MHR介于13.84%和12.01%.
结论:
- 健康生活方式指数和乳腺癌风险之间的关联是通过炎症,特别是CRP和CAR的弱媒介.
- 系统性炎症可能在乳腺癌发展的生物途径中起到中间因素的作用.
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