术后用皮质类固醇减少食管切除术后的术后并发症:一个更新的系统性审查和元分析
Wan-Wan Zou1,2,3, Hsiao-Pei Mok4, Qi-Kun Zhu2,3
1School of Medicine South China University of Technology, Guangzhou, 510006, People's Republic of China.
BMC surgery
|February 15, 2024
概括
外科期间使用的皮质类固醇可以减少患食道切除术后食道癌患者的并发症和重症监护室停留时间. 然而,像死亡率这样的严重结果与安慰剂可比,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 消化管癌手术 (消化管切除术) 具有重大风险.
- 为了减轻这些风险,正在调查外科手术期间使用皮质类固醇.
- 本综述更新了在这种情况下关于皮质类固醇疗效和安全性的证据.
研究的目的:
- 评估外科手术期间使用皮质类固醇的疗效和安全性,与安慰剂相比.
- 评估结果,包括死亡率,住院时间和并发症.
- 提供最新的系统审查和元分析.
主要方法:
- 通过2023年6月30日搜索数据库,查找随机对照试验 (RCT).
- 包括在胃肠切除术患者中比较外科皮质类固醇与安慰剂的研究.
- 分析了死亡率,住院和并发症等结果,使用风险比率和平均差异.
主要成果:
- 分析了9个带有508名参与者的RCT.
- 皮质类固醇并没有显著改变住院死亡率或整体住院时间.
- 观察到ICU停留时间缩短,心血管疾病和一般并发症.
结论:
- 在外科手术期间使用皮质类固醇对减少特定并发症和ICU停留有潜在的益处.
- 没有注意到严重结局的增加.
- 需要高质量的RCT来确认对死亡率和并发症的影响.
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