通过饮用水给药BAMLET可以抑制肠道瘤的发展,并促进长期健康
Hien Thi Tran1, Murphy Lam Yim Wan1, Ines Ambite1
1Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Klinikgatan 28, 221 84, Lund, Sweden.
Scientific reports
|February 15, 2024
概括
对瘤细胞具有致命作用的牛类α-乳蛋白 (BAMLET) 为结直肠癌提供了一个有前途的口腔治疗方法. 巴姆莱特抑制瘤生长,转移和相关基因表达,显示潜在的健康益处,没有毒性.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 分子生物学分子生物学
背景情况:
- 结肠直肠癌 (CRC) 由于瘤特异性和副作用,对向治疗提出了挑战.
- 开发有效和安全的CRC治疗仍然是一个关键的未满足的需求.
研究的目的:
- 为了研究牛的alpha-lactalbumin对瘤细胞具有致命作用 (BAMLET) 的疗效,作为结直肠癌的口服治疗.
- 在临床前模型中评估BAMLET对瘤发育,基因表达,信号通路和系统毒性的影响.
主要方法:
- 在饮用水中给ApcMin/+小鼠注射BAMLET,这是人类结直肠癌的模型.
- 评估瘤发育,与瘤生长和转移相关的基因表达,以及关键信号通路 (Wnt/β-catenin,PD-1).
- 系统性疾病传播和代谢反应的评估.
主要成果:
- 在ApcMin/+小鼠中,BAMLET治疗提供了长期保护,防止瘤的发展.
- 巴姆莱特显著降低了与瘤生长,迁移,转移和血管生成相关的基因的表达.
- 治疗抑制了Wnt/β-catenin和PD-1信号通路,延长了生存时间,并且没有显示出毒性迹象.
- 巴姆莱特抑制了全身性疾病的传播,调节了碳水化合物和脂质代谢.
结论:
- 口服BAMLET是结直肠癌治疗的有效策略,具有抗瘤作用和潜在的健康益处.
- BAMLET通过去除新出现的癌细胞和重新编程肠道和肠外组织中的基因表达来起作用.
- 在结直肠癌管理中,BAMLET 是一个有前途的,无毒的治疗候选药物.
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