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与聚合物协调的铁基化合物作为双H磁共振成像和光谱学的生物相容探针

Lucie Kracíková^1,2, Ladislav Androvič¹, David Červený^3,4

¹Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 00, Prague 6, Czech Republic.

Scientific reports

|February 15, 2024

概括

我们开发了用于双-31和质子-1磁共振成像和光谱学的新型含铁探头. 这些探头通过改变MRI信号,可以同时可视化解剖和探头分布.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
放射学放射学是一门学科.

背景情况:

开发用于磁共振成像和光谱的先进对比剂对于增强诊断能力至关重要.
-31 (31P) 和质子-1 (1H) MR提供了互补的信息,但双模式探测器很少.
铁基对比剂在MR中被广泛使用,但它们对31P信号的影响需要进一步调查.

研究的目的:

合成和描述新型含/含铁探针,用于同时进行31P和1HMRI成像和光谱 (MRI/MRS).
评估不同铁配方 (Fe3+离子与maghemite纳米粒子) 和聚合物架构对MR特性的影响.
为了证明这些双对比探针在同时进行解剖视觉化和生物分布监测方面的潜力.

主要方法:

生物相容的聚合物 (pMPC) 的合成与铁的协调功能与deferoxamine.
在聚合物链上对磁性Fe3+离子或超磁性磁石 (γ-Fe2O3) 纳米颗粒的协调.
评估1H和31PMR放松时间 (T1和T2) 以及在临床相关磁场下对幻影的成像/光谱性能.

主要成果:

所有合成的探针都显示出1H T1和T2放松时间的显著缩短,即使在低铁度下也是如此.
铁的加入大大减少了31P的放松时间,对γ-Fe2O3纳米粒子和多价聚合物的影响更为明显.
31P-MRS和31P-MRI都可视化了每链单个Fe3+离子的水溶性探针;由于超短放松,多个Fe3+离子或纳米颗粒的探针显示31P成像能力有限或不存在.

结论:

新型含/含铁的聚合物已成功合成并作为双 31P 和 1H MR 探针进行评估.
MR 特性,特别是 31P 放松,高度依赖于铁的类型 (Fe3+ 与 γ-Fe2O3 相比) 和聚合物结构 (单价与多价).
这些发现突出了开发双对比剂的潜力,用于生物医学应用中的同时解剖成像和有针对性的探针跟踪.

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