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Updated: Jul 3, 2025

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products
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An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

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通过使用大鼠肝脏微粒来改善体内生物清除的抽取,用于高度与血蛋白结合的分子

Markus Trunzer1, Joana Teigão2, Felix Huth2

  • 1Pharmacokinetic Sciences, Novartis Pharma AG, Basel, Switzerland markus.trunzer@novartis.com.

Drug metabolism and disposition: the biological fate of chemicals
|February 15, 2024
PubMed
概括

精心调的模型往往低于预测酸性药物的体内清除. 将血添加到体外化中可以改善对高度与蛋白质结合的化合物的预测,从而增强体外-体外抽取 (IVIVE).

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