血压的因果影响和脆弱的风险:双向的双样本孟德尔随机化研究
Ge Tian1,2, Rong Zhou2, Xingzhi Guo3
1Xi'an Medical University, Xi'an, 710021, Shaanxi, China.
Journal of human hypertension
|February 16, 2024
概括
高血压 (BP) 因果上增加了虚弱的风险. 控制高血压可能有助于减少虚弱的风险. 这项研究使用了门德尔的随机化来研究BP-脆弱性联系.
科学领域:
- 老年学是一门学科.
- 心血管疾病流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,高血压 (BP) 和虚弱之间存在联系.
- 这种关联的因果性需要进一步调查.
研究的目的:
- 通过使用孟德尔随机化 (MR) 调查BP和虚弱之间的双向因果关系.
主要方法:
- 使用了两个样本的MR设计,独立的单核酸多态 (SNPs) 作为系统性BP (SBP),扩张性BP (DBP) 和脉冲压 (PP) 的仪器变量.
- 来自CHARGE和ICBP联盟的BP (N>750,000) 和英国生物银行/瑞典TwinGene队伍的脆弱指数 (FI) (N = 175,226) 的GWAS数据.
- 采用逆方差加权 (IVW) 和其他敏感性分析来评估因果关系和稳定性.
主要成果:
- 对较高SBP,DBP和PP的遗传倾向与增加的FI因果相关 (例如,SBP:β = 0.135,P = 1.73E-10).
- 这些发现在不同的BP数据集和MR方法中一致.
- 没有观察到FI对BP测量有显著的因果作用,敏感性分析表明没有实质性的水平性.
结论:
- 高血压和高血压与高血压和高血压有因果关系,与较高的虚弱风险有关.
- 控制高血压可能是一个可行的策略,以减轻脆弱的风险.
- 这些发现支持BP与脆弱的单向因果关系.
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