CircYthdc2通过两种翻译策略生成多,以促进病毒逃脱
Weiwei Zheng1, Linchao Wang1, Shang Geng1
1Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China.
Cellular and molecular life sciences : CMLS
|February 16, 2024
概括
鱼类中的循环RNAs (circRNAs) 可以编码功能性多,在脊椎动物中保存. 这项研究揭示了circYthdc2在抗病毒免疫中的多种翻译机制和保存功能.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 已知循环RNAs (circRNAs) 在哺乳动物中编码功能性多.
- 在较低的生物体中,circRNAs的进化保存和翻译机制仍然不清楚.
研究的目的:
- 研究低脊椎动物中circRNA编码的多的存在和功能.
- 探索转化机制 (IRES和m6A) 和circRNAs的进化保护.
主要方法:
- 鱼类中circYthdc2的识别和特征.
- 通过IRES和m6A进行circYthdc2转换的分析.
- 研究circYthdc2在抗病毒免疫力和STING降解中的作用.
- 在不同物种中对circYthdc2的保护和功能进行比较分析.
主要成果:
- 在鱼类中发现了一种新型circRNA,circYthdc2,通过IRES或m6A转化为Ythdc2-170aa.
- circYthdc2和Ythdc2-170aa促进STING降解,削弱抗病毒免疫力.
- SCRV感染增强了circYthdc2的翻译;高水平的circYthdc2导致了其自身的降解.
- circYthdc2及其编码的多被从鱼类保存到人类,保留了类似的功能.
结论:
- 循环RNA编码的功能性多在脊椎动物中被进化保存.
- 一个单一的circRNA可以使用多种不同的翻译策略 (IRES,m6A).
- circYthdc2通过STING通路调节,在调节抗病毒免疫力方面发挥着保守的作用.
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