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在内脏过敏模型中,孟塔卡林治疗减弱了 nociception

Adesina Omoloye¹, Sabrina Weisenburger², Martin D Lehner²

¹Leicester Institute for Pharmaceutical Innovation, Leicester School of Pharmacy, De Montfort University, Leicester, UK.

Neurogastroenterology and motility

|February 16, 2024

概括

一种薄荷和油混合物 (menthacarin) 在过敏的老鼠模型中显著降低了内脏疼痛信号. 慢性孟塔卡林的使用可能通过向疼痛通路,为生气性肠综合征 (IBS) 提供一种新的治疗方法.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

刺激性肠综合征 (IBS) 与慢性内脏过敏和前带皮质 (ACC) 中大脑活动的改变有关.
胡卜和胡卜精油显示出缓解IBS症状的潜力.
由于腹部疼痛和膨胀,IBS显著影响患者的生活质量.

研究的目的:

为了评估胡卜和胡卜精油混合物 (menthacarin) 对大脑内脏疼痛敏感性的电生理标记物的影响.
为了评估急性和长期治疗效果,在内脏过敏的老鼠模型中评估.

主要方法:

使用了两种关于内脏过敏的老鼠模型.
在ACC中的电生理记录被用来测量对结直肠张张 (CRD) 的神经元反应.
在急性和慢性口服后评估了孟塔卡林 (60毫克/公斤/天) 的效果.

主要成果:

慢性皮质类固醇的使用和急性机械刺激都诱导了内脏过敏和过敏,其特征是ACC神经刺激增加.
长期服用孟塔卡林,但不是急性,显著减少神经元刺激对CRD的反应.
门他卡林抵消了两种实验模型引起的过敏症的发展.

结论:

长期服用临床相关剂量的孟塔卡林会减弱大鼠ACC对内脏疼痛刺激的神经元反应.
这些发现表明,孟塔卡林有潜力治疗过度的内脏疼痛敏感性,特别是在IBS.
这项研究强调了ACC在内脏疼痛处理中的作用以及以精油为基础的治疗方法的治疗潜力.

关键词:

孟塔卡林是一种薄荷糖.前带状皮层前带状皮层结肠直肠膨胀结肠直肠膨胀电力生理学电力生理学刺激性肠综合征是什么意思这是一种内脏过敏症.

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