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药物微生物组学:免疫抑制药物和移植中的微生物组相互作用

Moataz E Mohamed¹, Abdelrahman Saqr¹, Christopher Staley²

¹Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN.

Transplantation

|February 16, 2024

概括

人类微生物组影响药物反应,影响移植患者的结果. 了解药物微生物组相互作用 (DMI) 对于优化免疫抑制和预防移植中的不良事件至关重要.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
免疫学免疫学免疫学

背景情况:

人类微生物组显著影响健康和疾病.
外源化合物,包括药品,受到微生物群的影响,这导致了药物微生物组学领域.
药物微生物组相互作用 (DMI) 可以改变药物药理动力学和药理动力学,可能导致副作用和各种疾病反应.

研究的目的:

本综述侧重于药物微生物组在器官移植中的作用.
突出由于微生物组变化的DMI在移植受体中的高潜力.
讨论目前的证据和药物微生物组移植研究的未来方向.

主要方法:

审查关于药物微生物组学和移植的现有文献.
对研究微生物对免疫抑制药物的作用的研究分析.
识别当前研究中的知识差距和局限性.

主要成果:

移植接收者通常具有改变的微生物组,增加DMI风险.
肠道微生物组会影响塔克罗利斯的药理动力学和mycophenolate的肠肝循环.
对于环素A,皮质类固醇和西洛利木斯,人类DMI数据有限.

结论:

药物微生物组具有改善移植结果的巨大潜力.
需要进一步进行大规模的临床研究,以阐明DMI机制和临床应用.
了解DMI是个性化免疫抑制治疗在移植中的关键.

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