相关实验视频

Updated: Jul 3, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

在患有抑郁症或不患抑郁症并发的偏头痛患者中,杏仁体体积和功能连接的改变

Xin Chen^1,2, Wei Gui³, Han-Li Li⁴

¹Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, China.

Brain and behavior

|February 16, 2024

概括

偏头痛和抑郁症共享一个扩大的杏仁体. 中心中枢桃体 (CMA) 和背侧前额皮质 (DLPFC) 之间的功能连接性下降可能标志着并发性偏头痛和抑郁症.

科学领域:

神经成像是一种神经成像.
神经学神经学
精神病学是一个精神病学.

背景情况:

偏头痛和抑郁症的并发症已经确立,但其潜在的病理生理学仍然不清楚.
研究共享的神经机制对于理解和治疗这些疾病至关重要.

研究的目的:

在偏头痛和并发性抑郁症患者中探索杏仁体的结构变化和中枢杏仁体 (CMA) 的功能连接.
为了识别潜在的神经成像标志物为偏头痛-抑郁症并发症.

主要方法:

从患有并发性抑郁症 (EMwD) 的偶发性偏头痛患者,没有抑郁症 (EM) 的偶发性偏头痛患者和健康对照者 (HC) 获得了高分辨率的T1加权和功能性MRI扫描.
利用基于voxel的形态测量和静止状态功能连接 (rsFC) 分析来比较群体之间的杏仁体体积和连接模式.

主要成果:

与HC相比,双边杏仁体体积在EMwD和EM组中都增加,EMwD和EM之间没有显著差异.
与EM相比,EMwD显示右CMA和左背侧前额皮层 (DLPFC) 之间的rsFC减少.
与HC相比,EM组表现出CMA和逆侧DLPFC之间的rsFC增加,与HC相比,左CMA和左白之间rsFC减少.

结论:

杏仁体积增加是偏头痛的成像特征,既有抑郁症,也没有.
改变CMA和DLPFC之间的功能连接可能作为偏头痛和抑郁症共患病的神经病理标志物.
这些已识别的大脑区域代表了潜在的未来治疗点,用于治疗并发性偏头痛和抑郁症.

关键词:

阿米格达拉的桃体中心中间的杏仁体抑郁抑郁症抑郁症抑郁症抑郁症功能连接性的功能连接性偏头痛偏头痛偏头痛偏头痛基于voxel的形态测量方法

更多相关视频

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

相关概念视频

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Role of Amygdala in Memory

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...