在患有和没有阅读障碍的人群中,对灰色物质进行体积不对称性研究
Kelly Nisbet1, Avary Kostiw2, Thi Kim Truc Huynh3
1Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
Journal of neuroscience research
|February 16, 2024
概括
脑部成像揭示了熟练阅读者与阅读障碍患者之间脑部不对称的差异. 这些发现突出了明显的前后大脑连接,对于理解阅读障碍至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 发展心理学 发展心理学
背景情况:
- 阅读障碍分类研究突出显示前后脑区域关系.
- 下额回形 (IFG) 和它与上回形 (STG) 和上边回形 (SMG) 的连接参与阅读.
- 需要进一步了解IFG次区域连接,以阐明阅读障碍症的神经支.
研究的目的:
- 研究下额回形 (pars orbitalis,triangularis,opercularis) 和后读区域 (STG,SMG) 的三个组成部分之间的差异关系.
- 探索这些地区的体积不对称性如何在熟练阅读者和阅读障碍患者之间存在差异.
- 检查IFG不对称性和STG不对称性与阅读能力之间的关联.
主要方法:
- 使用磁共振成像 (MRI) 来获得38名成年参与者 (16名阅读障碍患者) 的高分辨率结构扫描.
- 在IFG,STG和SMG的轨道,三角,操作的体积不对称性被计算出来.
- 进行了统计分析,以比较熟练阅读者和阅读障碍患者之间的不对称性,并评估区域不对称性之间的关联.
主要成果:
- 在将熟练阅读者与阅读障碍患者进行比较时,在所有三个IFG次区域中都观察到区域不对称的显著差异.
- 与阅读障碍患者相比,熟练阅读的读者表现出较大的左向不对称性在轨道和三角的 pars,以及较大的右向不对称性在 pars opercularis.
- 帕斯三角体在熟练阅读者中与向左的STG不对称性有显著的关联,但在阅读障碍患者中并非如此.
结论:
- 在IFG中的皮质不对称性及其与其他与阅读相关的大脑区域的连接在阅读障碍和熟练阅读者之间存在显著差异.
- 这些发现有助于在打印到语音框架内了解阅读障碍症的神经基础.
- 该研究强调了在阅读障碍的背景下检查特定的IFG次区域及其区域间联系的重要性.
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