在婆罗洲猩猩 (Pongo pygmaeus) 中自然获得的免疫力对Plasmodium pitheci
Karmele Llano Sánchez1,2,3, John Kevin Baird4,5, Aileen Nielsen6
1IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia.
Parasitology
|February 16, 2024
概括
婆罗洲猩猩对Plasmodium pitheci疟疾产生免疫力,导致无症状感染. 临床疟疾在成熟的猩猩中更为常见,这表明如果不再暴露,免疫力会减弱.
科学领域:
- 灵长类的免疫学
- 寄生虫学的寄生虫学
- 野生动物疾病生态学 野生动物疾病生态学
背景情况:
- 人类自然获得的疟疾免疫力往往导致无症状感染.
- 婆罗洲猩猩 (Pongo pygmaeus) 容易感染疟原虫.
研究的目的:
- 为了研究在婆罗洲猩猩中对Plasmodium pitheci疟疾自然获得的免疫力.
- 确定寄生虫血症,年龄和猩猩临床疟疾发病率之间的关系.
主要方法:
- 在6年的时间里 (2017-2022年) 对135只猩猩进行了长度研究.
- 使用显微镜和PCR分析了2140个外周血液样本.
- 针对不同年龄组的感染率,寄生虫病水平和临床疟疾发病率的比较.
- 病例对照研究,比较患有临床疟疾的猩猩与无症状对照.
主要成果:
- 未成熟的猩猩经历了更频繁和更高的寄生虫血症.
- 成熟的猩猩比幼更容易患上临床疟疾.
- 与无症状对照相比,患有临床疟疾的猩猩最近发生寄生虫病事件的可能性是256倍.
结论:
- 猩猩快速获得免疫力,抵御Plasmodium pitheci的疾病.
- 在没有病原体再暴露的情况下,这种免疫力似乎会减弱.
- 年龄影响了寄生虫血症水平和临床疟疾的表现.
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