酵母β-葡萄糖颗粒的识别触发了训练免疫力所需的免疫代谢信号
Cian J H Horneck Johnston1, Anna E Ledwith1, Mimmi L E Lundahl1
1School of Biochemistry & Immunology, Trinity College, Dublin 2, Ireland.
iScience
|February 16, 2024
概括
酵母衍生的全葡萄糖颗粒 (WGP) 通过重编程巨细胞代谢和表观遗传学来增强训练免疫力. 这种免疫训练增强了对感染的保护,建议治疗和基于食物的应用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢研究的研究.
背景情况:
- 类β-葡萄糖是训练免疫力的关键诱导剂,可以保护对二次感染.
- β-葡萄糖性质的变化会影响与Dectin-1的相互作用,影响训练有素的免疫策略.
- 了解这些相互作用对于开发有效的人类免疫增强干预措施至关重要.
研究的目的:
- 研究酵母衍生全葡萄糖颗粒 (WGP) 诱导训练免疫的能力.
- 阐明WGP重编程细胞代谢和表观遗传学的机制.
- 探索WGP在增强免疫反应方面的治疗和饮食潜力.
主要方法:
- 使用了多种类型的β-葡萄糖,包括酵母衍生的WGP.
- 评估了WGP对人体单细胞衍生的巨细胞 in vitro和小鼠骨髓 in vivo的影响.
- 分析了Dectin-1细胞突触形成,溶酶体mTOR激活,代谢重编程和表观遗传变化.
主要成果:
- 非可溶性,非聚合性WGP的特定呈现触发了Dectin-1细胞突触形成.
- 在巨细胞中,WGP诱导了显著的代谢重编程和表观遗传重新连接.
- 使用WGP (肠内或口服) 促进了骨髓骨髓形成,并增强了成熟的巨细胞功能.
结论:
- 细胞对训练免疫的投资取决于通过Dectin-1在完整的微生物颗粒上对β-葡萄糖的特定识别.
- 酵母衍生的WGP通过Dectin-1-介导机制有效地驱动训练免疫力.
- WGP对治疗和以食物为基础的策略来增强长期免疫力充满希望.
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