脑血管神经外科的随机临床试验从2018年到2022年
Ari D Kappel1, Hillary B Nguyen1, Kai U Frerichs1
1Neurosurgery, Brigham and Women's Hospital, Boston, USA.
Cureus
|February 16, 2024
概括
本综述总结了自2018年以来脑血管神经外科的80个2b期和3期随机对照试验. 缺血性中风试验占主导地位,但在动脉瘤和出血方面也进行了重要的研究,指导了未来的临床实践.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 血管外科 血管外科
背景情况:
- 越来越多的随机对照试验 (RCT) 正在在大脑血管神经外科发表.
- 了解最近高影响力研究的范围对于指导临床实践和未来研究至关重要.
研究的目的:
- 审查,概述范围,并总结所有影响脑血管神经外科实践的2b期和3期RCT,从2018年1月到2022年7月.
- 确定该领域的关键研究领域和趋势.
主要方法:
- 在PubMed,MEDLINE,Embase,ClinicalTrials.gov和Cochrane CENTRAL搜索了2018年1月1日至2022年7月1日之间发表的RCT.
- 包括与神经外科相关的八种主要脑血管疾病相关的2b期和3期RCT.
- 排除了儿科研究,康复/心血管中风研究,协议,队列研究,注册表研究,集群RCT和非随机试验.
主要成果:
- 确定了80个独特的2b或3期RCT,符合纳入标准.
- 缺血性中风试验,特别是那些涉及机械血栓切除和血栓溶解的试验,构成了大多数出版物.
- 显著的大型试验也被确定为脑内出血,体外出血,动脉瘤,脑下出血和脑静脉血栓.
结论:
- 自2018年以来,在脑血管神经外科中发表了许多重要的RCT.
- 这些发现提供了最近高水平证据的全面概述,有助于在脑血管疾病的未来研究和临床决策的方向.
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