作为COVID-19患者严重程度和预后的标志物,入院时进行肝功能测试 - 一个回顾性分析
Pratibha Himral1, Rajesh Bhawani1, Manisha Bhardwaj2
1Department of General Medicine, Shri Lal Bahadur Shastri Government Medical College and Hospital Mandi at Ner Chowk, District Mandi Himachal Pradesh, India.
Journal of family medicine and primary care
|February 16, 2024
概括
大多数COVID-19肺炎患者 (78%) 在入院时表现出异常的肝功能,这一组的死亡率更高. 监测AST和ALT等肝酶和白蛋白水平可以帮助降低COVID-19患者的死亡率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- COVID-19可以表现为肺外症状,包括肝功能障碍.
- 有相当数量的COVID-19肺炎患者出现异常的肝功能测试.
研究的目的:
- 为了确定COVID-19肺炎患者肝功能障碍的发生率.
- 调查肝功能异常与疾病严重程度之间的关联.
主要方法:
- 从344名中度至重度COVID-19患者的医院记录的回顾性分析.
- 评估肝功能测试,包括阿斯巴酸氨基转移酶 (AST),氨基转移酶 (ALT) 和录取时的白蛋白水平.
主要成果:
- 78.49%的患者在入院时表现出异常的肝功能.
- 升高的AST (82.96%),ALT (74.91%) 和低蛋白血 (69.7%) 是常见的.
- 在AST,ALT,低albuminemia和疾病严重程度之间观察到正相关性.
- 肝功能障碍患者 (33%) 的死亡率高于正常肝功能患者 (18.9%).
结论:
- 异常的肝功能在COVID-19肺炎患者中很普遍.
- 监测肝功能参数 (AST,ALT,白蛋白) 对于管理COVID-19至关重要.
- 早期发现和治疗肝功能障碍可能会降低高风险患者的死亡率.
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